Shoc2 and normal function

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August undefined, 2024

WebThis gene encodes a protein that consists almost entirely of leucine-rich repeats, a domain implicated in protein-protein interactions. The protein may function as a scaffold linking RAS to downstream signal transducers in the RAS/ERK MAP kinase signaling cascade. Mutations in this gene have been associated with Noonan-like syndrome with loose anagen hair. Web9 Dec 2024 · SHOC2 is a scaffold protein comprising an N-terminal lysine-rich region and subsequent 19 leucine-rich repeats (LRRs) that plays a crucial role in the activation of the ERK1 (MAPK3; 601795 )/ERK2 (MAPK1; 176948) signaling pathway ( Cordeddu et al., 2009; Rodriguez-Viciana et al., 2006; Matsunaga-Udagawa et al., 2010 ).

Case report: A de novo RASopathy-causing SHOC2 variant in a …

Web11 Feb 2024 · As Shoc2 has been shown to bind M-Ras in a GTP-dependent manner, we initiated experiments to further investigate the function of Shoc2 as an effector of M-Ras. … Web13 Jul 2024 · MRAS, SHOC2 and PP1C are mutated in rasopathies—developmental syndromes caused by aberrant MAPK pathway activation6–14—and SHOC2 itself has … infinity war tv listings

Tegumentary manifestations of Noonan and Noonan-related …

Web10 May 2024 · SHOC2 acts as a strong synthetic lethal interactor with MEK inhibitors in multiple KRAS cancer cell lines. SHOC2 forms a heterotrimeric complex with MRAS and PP1C that is essential for regulating RAF and MAPK-pathway activation by dephosphorylating a specific phosphoserine on RAF kinases. Web20 Jun 2001 · A syndrome characterized by Noonan dysmorphic features such as macrocephaly, high forehead, hypertelorism, palpebral ptosis, low-set and posteriorly … WebClinical studies have also investigated the association between obesity and PCa. 26 Examining tumour and benign tissue in overweight and normal weight men with PCa, nearly 95% of whom had localised disease, 15 gene sets were found to be overexpressed in obese men, 5 of which functioned for chromatin modification and remodelling, which are linked … infinity war toys

Functional Integration of the Conserved Domains of Shoc2 …

role of USP7 in the Shoc2-ERK1/2 signaling axis and Noonan-like ...

Web8 Feb 2024 · For example, the epidermal growth factor receptor is strongly required in certain cancer cells, but not in normal bone marrow stem cells, making it a potentially good target (Wang et al., 2006). The Cancer Dependency Map (DepMap) is an ongoing project to identify essential genes across hundreds of cancer cell lines using genome-wide CRISPR … Leucine-rich repeat (LRR) protein SHOC-2 is a protein that in humans is encoded by the SHOC2 gene. The best-studied role of SHOC2 is in modulating signals of the extracellular signal-regulated kinase 1 and 2 (ERK1/2) pathway by forming a holophosphatase complex that activates RAF proteins(PMID 16630891, 33526449). This protein was initially identified in Caenorhabditis elegans as SUR-8/SOC2 and was found to be a critical positive regulator of the ERK1/2 signaling pathwa… infinity war trailer reactionWeb7 Aug 2024 · Looking in detail at the cellular role of SHOC2, the group identified both SHOC2-dependent and -independent mechanisms of ERK activation. Importantly, … infinity war watch online

"Web24 Mar 2024 · Gain-of-function mutations of NRAS gene are causally related to NS type 6. Thus, it is conceivable that NRAS haploinsufficiency and gain-of-function mutations may have similar clinical consequences. The same phenomenon has been described for two other genes belonging to the Ras/MAPK pathway: MAP2K2 and SHOC2. " - Shoc2 and normal function

Shoc2 and normal function

Clinical Heterogeneity in two patients with Noonan-like Syndrome ...

WebIt has been suggested that Sema3e production is involved in regulating NK cell activation and functions, or in DC homeostasis in NK-DC crosstalk. 53 Another gene, and also protein expression, upregulated by cyto-IL-15 was the tumor suppressor gene programmed cell death protein 4 (Pdcd4) (~5 fold-change), which is known to deregulate DNA-damage … Web8 Jul 2024 · Young et al. (2024) showed that MRAS and SHOC2 function as PP1 regulatory subunits, providing the complex with striking specificity against RAF. MRAS also …

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WebSHOC2 (soc-2 suppressor of clear homolog) (eg, Noonan-like syndromewith loose anagen hair), S2G variant 81400-32 81400-33 SMN1 (survival of motor neuron 1, telomeric) (eg, spinal muscularatrophy), exon 7 deletion 81400-34 81400-35 81401-01 81401-03 81401-05 Web25 Mar 2013 · It has also been reported to dampen ERK by binding and inhibiting the scaffolding function of SHOC2, ... Sections were blocked in 2% BSA/10% normal goat serum/PBS for 30 minutes at 37°C or overnight at 4°C. Goat serum was omitted when primary antibodies included goat IgG. Primary antibody incubation was carried out …

Web20 Dec 2012 · Galperin et al. recently demonstrated that Shoc2 moves along the endocytic pathway to RAB7 positive late endosomes upon EGFR stimulation. Despite being an intracellular protein, knock down of clathrin to prevent endocytosis of the liganded EGFR, prevents Shoc2 intracellular movement. This is consistent with Shoc2 being trafficked … Web20 Sep 2012 · Noonan-like syndrome with loose anagen hair (NS/LAH; OMIM #607721) has been recently related to the invariant c.4A > G missense change in SHOC2. It is characterized by features reminiscent of Noonan syndrome. Ectodermal involvement, short stature associated to growth hormone (GH) deficiency (GHD), and cognitive deficits are common …

Web21 Jun 2013 · Shoc2 is comprised of two main domains: the 21 leucine rich repeats (LRRs) core and the N-terminal non-LRR domain. We demonstrated that the N-terminal domain … WebTumor Suppressor Protein p53 (4) Gene Dosage (4)

WebSHOC2. AU017287, Sur8, mKIAA0862. soc-2 (suppressor of clear) homolog (C. elegans) GO Process (1) GO Function (1) GO Component (4) Gene Ontology Biological Process. positive regulation of Ras protein signal transduction . Gene Ontology Molecular Function. protein phosphatase binding .

Web1 Apr 2006 · Shoc2 function is essential for activation of the MAPK pathway by growth factors. Furthermore, in tumor cells with Ras gene mutations, inhibition of Shoc2 expression inhibits MAPK, but not PI3K activity. We propose that the Shoc2-PP1c holoenzyme provides an attractive therapeutic target for inhibition of the MAPK pathway in cancer. infinity war watch orderWebNoonan and Noonan-related syndromes are common autosomal dominant disorders with neuro-cardio-facial-cutaneous and developmental involvement. The objective of this article is to describe the most relevant tegumentary findings in a cohort of 41 infinity war writersWebProgramming device evaluation (in person) with iterative adjustment of the implantable mechano-electrical skin interface and/or external driver to test the function of the device and select optimal permanent programmed values with analysis, including review and report, implantable aortic counterpulsation ventricular assist system, per day infinity watch msf infographicWebThe extracellular signal-regulated kinase (ERK1/2) cascade regulates a myriad of functions in multicellular organisms. Scaffold proteins provide critical spatial and temporal control over the specificity of signaling. Shoc2 is a scaffold that accelerates activity of the ERK1/2 pathway. Loss of Shoc2 expression in mice results in embryonic ... infinity war xbox one release dateWebView mouse Shoc2 Chr19:53932737-54021564 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression infinity watch counter msfWeb29 Jun 2024 · SHOC2 is as an essential scaffolding protein that engages both PP1C and RAS to dephosphorylate RAF NTpS 11, 12, 13, but the structure of SHOC2 and the … infinity waste colorado springsWebLa Biblioteca Virtual en Salud es una colección de fuentes de información científica y técnica en salud organizada y almacenada en formato electrónico en la Región de América Latina y el Caribe, accesible de forma universal en Internet de modo compatible con las bases internacionales. infinity waste logistics