Web18 dec. 2024 · Myh6-driven Cre recombinase activates the DNA damage response and the cell cycle in the myocardium in the absence of loxP sites. Regeneration of muscle in the … WebIn this study, we generated a Myh6-Cre knockin mouse model by inserting the IRES-Cre-wpre-polyA cassette between the translational stop codon and the 3' untranslated region of the endogenous Myh6 gene. By crossing knockin mice with the Rosa26 reporter lines, we found that Myh6-Cre targeted cardiomyocytes at the embryonic and postnatal stages.
Measuring cardiomyocyte cell-cycle activity and proliferation in …
WebThen, Hmgb1 flox/+; Myh6-MerCreMer mice were crossed with Hmgb1 flox/flox mice to produce hmgb1 flox/flox; Myh6-MerCreMer homozygous mice. For tamoxifen-induced … Web23 jul. 2015 · Mhy6 encodes a cardiac muscle specific protein: alpha-myosin heavy chain. Here, we generated a new Myh6-MerCreMer (Myh6MerCreMer/+) inducible Cre knock … dragon\u0027s tooth trefethen
A Murine Myh6 MerCreMer Knock-In Allele Specifically Mediates
Web11 jun. 2009 · Materials and Methods. Myh6-MerCreMer +/+ transgenic mice (no. 005650, Jackson Labs, Bar Harbor, Me) were used. Myh6-MCM +/− /no-flox were generated by … WebMyh6 Cre Esr1 1jmk J Mercremer Mice, supplied by The Jackson Laboratory, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS … Web8 jun. 2024 · We generated Myh6-MerCreMer;Confetti +/− (MCM;Confetti) mice in which a single dose of tamoxifen leads to stochastic, indelible labeling of cardiomyocytes with 1 of 4 fluorescent proteins (Figure [A]). 4 By pulsing tamoxifen at postnatal day (P) 0 to P1, before significant binucleation or polyploidization occurs, 1,2 we ensured that labeled … dragon\u0027s upside down house