High affinity copper uptake protein
WebIt was shown that a gene, CTR1, encoded a multispanning plasma membrane protein that was specifically required for high affinity copper transport into yeast.The CTR1 gene product is a protein composed of 406 amino acid residues. A second high affinity copper uptake protein, encoded by the CTR3 gene, was subsequently identified. The two gene … WebHigh CTR1 Expression is associated with poor response to chemotherapy in Muscle-invasive Bladder Cancer. Gene silencing of either CTR1 or DMT1 did not affect copper …
High affinity copper uptake protein
Did you know?
WebCopper (Cu) is an essential trace element for growth and development and abnormal Cu levels are associated with anemia, metabolic disease and cancer. Evolutionarily … WebLOC106158117 high affinity copper uptake protein 1 [] Gene ID: 106158117, updated on 12-Aug-2024. Summary Other designations. high affinity ...
WebBecause copper uptake at the cell membrane is a crucial step in copper acquisition, yeast genes encoding the high affinity copper transport proteins are tightly regulated in response to copper levels to ensure that … Web21 de mar. de 2024 · High Affinity Copper Uptake Protein 1 3 4 Copper Transporter 1 3 4 Solute Carrier Family 31 (Copper Transporters), Member 1 3 Copper Transport 1 Homolog 3 External Ids for SLC31A1 Gene HGNC: 11016 NCBI Entrez Gene: 1317 Ensembl: ENSG00000136868 OMIM®: 603085 UniProtKB/Swiss-Prot: O15431 Previous HGNC …
WebHigh affinity copper uptake protein 1 Gene SLC31A1 Status UniProtKB reviewed (Swiss-Prot) Organism Homo sapiens (Human) Amino acids 190 Protein existence Evidence at protein level Annotation score 5/5 Entry Feature viewer Publications External links History BLAST Download Add a publication Entry feedback Function Web30 de dez. de 2005 · High affinity copper binding by wild type PrP has been confirmed by the independent techniques indicating the presence of specific tight copper binding sites …
WebThe redox active metal copper is an essential cofactor in critical biological processes such as respiration, iron transport, oxidative stress protection, hormone production, and pigmentation. A widely conserved family of high affinity copper transport proteins (Ctr proteins) mediates copper uptake at the plasma membrane. However, little is known …
WebProtein target information for High affinity copper uptake protein 1 (house mouse). Find diseases associated with this biological target and compounds tested against it in … harriet tubman key life eventsWeb1 de out. de 2002 · High affinity copper uptake protein 1 Gene Slc31a1 Status UniProtKB reviewed (Swiss-Prot) Organism Mus musculus (Mouse) Amino acids 196 Protein … harriet tubman kid picturesWeb10 de abr. de 2024 · Abstract Heavy metal contamination impacts plant growth and productivity by causing damage at all levels of plant organization, making it one of the most significant abiotic stressors. This study evaluated the uptake and distribution of cadmium (Cd) and copper (Cu) in Solanum lycopersicum L. and identified the antioxidant enzyme … charcoal heartgoldWeb15 de mar. de 1996 · Two proteins in the plasma membrane of yeast—a multicopper oxidase, encoded by the FET3 gene, and a permease, encoded by the FTR1 gene—were shown to mediate high-affinity iron uptake. FET3 expression was required for FTR1 protein to be transported to the plasma membrane. charcoal hardwoodWebalthough the role of Ctr1 internalization in copper uptake is currently unclear. Furthermore, exposure of yeast cells to high copper concentrations ($10 mM) triggers the degradation of Ctr1 at the plasma membrane in a mechanism that is inde-pendent of endocytosis and vacuolar proteases (14). The Ctr1 and Ctr3 high affinity copper transport ... harriet tubman kids encyclopediaHigh affinity copper uptake protein 1 (CTR1) is a protein that in humans is encoded by the SLC31A1 gene. Copper is an element essential for life, but excessive copper can be toxic or even lethal to the cell. Therefore, cells have developed sophisticated ways to maintain a critical copper balance, with the intake, export, … Ver mais In 2024, a new autosomal-recessive disease was discovered that is caused by mutations of the CTR1 gene. The disease is characterized by profound deficiency of copper in the central nervous system and presents with … Ver mais • Solute carrier family Ver mais • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". … Ver mais charcoal heated urnWebencode a high affinity copper uptake process and was found to be 29% identical at the primary structure level with Ctr1 from yeast. The human protein was, however, substantially smaller than the yeast protein, being composed of 190 amino acids as compared with 406 amino acids (see Fig. 1). hCTR1 is on the harriet tubman john brown harpers ferry