WebJan 10, 2024 · Cyclophosphamide is a prodrug that requires an activation step by cytochromes (P450) in the liver [ 14 ]. As shown in Figure 1, the introduction of the hydroxyl group to the oxazaphosphorine ring … WebSep 4, 2024 · CYC-related cardiotoxicity usually occurs in the first 3 weeks after drug administration. 6 Clinical presentation is an acute and severe congestive heart failure.
Molecular mechanism involved in cyclophosphamide …
WebJun 26, 2015 · Cyclophosphamide (CY) is metabolized to 4-hydroxy-cyclophosphamide (HCY) in the hepatic cytochrome P-450 enzyme (CYP) system (CYP2B6 and/or CYP2C19). HCY enters cells as tautomer aldocyclophosphamide (AldoCY). Through β-elimination, AldoCY can be converted to phosphoramide mustard (PM) and acrolein. WebSep 7, 1991 · Cyclophosphamide (CY) cardiotoxicity may be a lethal complication of bone marrow transplantation. Previous echocardiographic studies have reported that left ventricular dysfunction due to CY occurs in over 50% of patients undergoing transplantation. do egg bound chickens poop
Cardiotoxicity of cyclophosphamide
WebFeb 1, 2024 · CP-induced cardiotoxicity ranges from 7 to 28% and mortality ranges from 11 to 43% at the therapeutic dose of 170-180 mg/kg, i.v. CP undergoes hepatic … WebA 12-year-old boy with aplastic anemia developed severe but reversible cardiac failure after treatment with 200 mg/kg cyclophosphamide (4×50 mg/kg on four consecutive days) given as preparation for bone marrow grafting. This and previously reported cases demonstrate the possibility of cardiotoxicity after high doses of the drug. WebDec 19, 2024 · Cyclophosphamide is an alkylating agent that is used for a variety of malignancies, including breast cancer, lung cancer, lymphomas, and in conditioning regimens before stem cell transplantation. High-dose cyclophosphamide (>1.5 g/m 2 /day) is considered to be highly cardiotoxic, with CTRCD incidences ranging from 7% to 28% ( … eye eater cichlid