Cisplatin hela

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August undefined, 2024

WebThe chemotherapeutic agent cisplatin, which is a small-molecule platinum compound and was originally found to inhibit bacterial growth and later identified as an anticancer agent, appears to most effectively treat … WebAug 6, 2024 · Cisplatin is a platinum-based chemotherapeutic agent that is widely used for the treatment of malignant tumors, such as cervical cancer, lung cancer, and ovarian cancer [3]. Cisplatin mainly induces cross-linking at the N7-position of guanosine, which modifies DNA to induce apoptosis and kill cancer cells [4].

Neil3-mediated proteasomal degradation facilitates the repair of ...

WebWestern Blots showed that cisplatin decreased protein expression of E6 and increased protein expression of P53, p21 and Bax but had no effect on protein expression of … WebJan 20, 2024 · Further investigation revealed that cisplatin-resistant cells sustain OXPHOS partly via iron metabolism reprogramming during glutamine deprivation. This reprogramming might be responsible for mitochondrial iron-sulfur [Fe-S] cluster biogenesis, which has become an "Achilles' heel," rendering cancer cells vulnerable to DFO-induced autophagic ... sims 4 not in compliance with green gardening

Pomiferin targets SERCA, mTOR, and P-gp to induce autophagic …

WebCisplatin, as a significant chemotherapeutic drug for the treatment of cancers, was combined with rapamycin (RAPA), an autophagy inducer, or 3-methyladenine (3-MA), an autophagy inhibitor, and these cisplatin … WebAbstract. To study the apoptosis induced by cisplatin in cervical cancer cell line HeLa and its mechanism, cell growth inhibition of cisplatin on HeLa cells was analyzed by … WebApr 13, 2024 · HIGHLIGHTS. who: Florentine S. B. Subtil et al. from the Department of Radiotherapy and Radiooncology, Philipps-University, Marburg, Germany have published the research: Dual PI3K/mTOR Inhibitor NVP-BEZ235 Leads to a Synergistic Enhancement of Cisplatin and Radiation in Both HPV-Negative and -Positive HNSCC Cell Lines, in the … rc church launceston

Nucleolin Promotes Cisplatin Resistance in Cervical Cancer by the …

Hypotonic intraperitoneal cisplatin chemotherapy for peritoneal ...

WebMixed lineage leukemia 5 (MLL5) transactivates the expression of E6 and E7 oncogenes in cervical cancer cells. In this study, we utilized CRISPR/Cas9 system with the aim to target HPV-E6 and MLL5 to enhance apoptosis efficiency in HPV-18 positive WebMixed lineage leukemia 5 (MLL5) transactivates the expression of E6 and E7 oncogenes in cervical cancer cells. In this study, we utilized CRISPR/Cas9 system with the aim to … sims 4 not in electronic arts folderWebSep 10, 2010 · Cisplatin has been widely accepted as one of the most efficient anticancer drugs for decades. However, the mechanisms for the cytotoxic effects of cisplatin are still not fully understood. Cisplatin primarily targets DNA, resulting in the formation of DNA double strand breaks and eventually causing cell death. sims 4 not in world townies

"WebMay 1, 1996 · The intraperitoneal (i.p.) administration of cisplatin (CDDP) is one of the most effective therapies for cancers that are confined to the abdominal cavity. However, the … " - Cisplatin hela

Cisplatin hela

Cisplatin-resistant HeLa cells are resistant to apoptosis via …

WebA cisplatin-resistant cell subline, HeLa/CDDP cells, showed a 19-fold resistance to cisplatin compared with the parent cells. The subline showed a collateral sensitivity to paclitaxel. An equitoxic dose (IC50) of cisplatin produced DNA fragmentation in HeLa … WebFeb 16, 2024 · severe or ongoing nausea and vomiting; vision problems, pain behind your eyes; hearing problems, ringing in your ears; pain, redness, swelling, or skin changes …

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WebCisplatin is a chemotherapy drug which is used to treat cancers including: sarcoma, small cell lung cancer, germ cell tumors, lymphoma, and ovarian cancer. While it is often … WebApr 11, 2024 · HIGHLIGHTS who: Umit Aliyaskarova from the Universitu00e9 Nazarbayev University have published the paper: NEIL3-mediated proteasomal degradation facilitates the repair of cisplatin-induced DNA damage in human cells, in the Journal: Scientific … Neil3-mediated proteasomal degradation facilitates the repair of cisplatin-induced dna …

WebApr 21, 2024 · Cisplatin, as a significant chemotherapeutic drug for the treatment of cancers, was combined with rapamycin (RAPA), an autophagy inducer, or 3 … Web1 day ago · To further confirm the autophagic effect, the expression level of LC3 was detected by immunoblot analysis in HeLa cells, an appropriate tool cells for ... Pomiferin potentiates the tumor suppression effect of cisplatin via attenuating ABCB1 activity and promoting cisplatin accumulation in tumor tissues of RM-1 drug-resistant prostate ...

WebFeb 10, 2024 · Cisplatin is one of the most effective chemotherapy drugs and is widely used in the treatment of cancer, including hepatocellular carcinoma (HCC) and … WebFeb 28, 2024 · One of the main problems in chemotherapy using platinum drugs as anticancer agents is the resistance phenomenon. Synthesizing and evaluating valid alternative compounds is challenging. This review focuses on the last two years of progress in the studies of platinum (II)- and platinum (IV)-based anticancer complexes. In …

WebResults: HeLa and SiHa cells were more sensitive to cisplatin and oxaliplatin treatment than C33A cells. HeLa and SiHa cells had significantly lower NRF2 gene levels, NQO1 …

WebThe cis-Diammineplatinum (II) dichloride (cisplatin; P4394), 3- (4,5-Dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT; M2128), and dimethyl sulfoxide (DMSO; D2650 for cell stock storage and D5979 for drug preparation) were purchased from Sigma (St. Louis, MO, USA). sims 4 not letting me play householdWebFor IFNβ-cisplatin sequential treatment protocol (E), HeLa cells were treated with 100 ng/mL IFNβ for 24, 48, or 72 h, and then cells were replated in 96-well plates and treated … sims 4 not launching ea app 2023WebIn vitro response to ionizing radiation (IR), cisplatin (cDDP), hyperthermia (HT) and PARP1-inhibition (PARP1- i) as single and combinational treatments in four cervical cancer cell lines (SiHa, HeLa, CaSki and C33A). ( A) Normalized colony formation after IR in combination with cDDP or ( B) with HT. sims 4 not in my game libraryWebFeb 12, 2024 · MBNL1 regulates resistance of HeLa cells to cisplatin via Nrf2 Chemotherapy is an important method in the treatment of cervical cancer, but some patients will face drug resistance, which often indicates a poor prognosis. Moreover, there is no complete solution at present. sims 4 not interacting with other simsWebHeLa Kyoto cells were treated for 1 h with 0.2 μg/mL colcemid 48 h after exposure to cisplatin. Both undamaged and damaged GM08505 cells were treated with colcemid 72 h after the first transfection (where indicated, GM08505 cells were treated with 1 μM cisplatin for 24 h prior to colcemid treatment). rc church league softballWebMay 26, 2011 · The cisplatin resistant cell line HeLa/CDDP was generated previously under exposure to a clinically relevant concentration of cisplatin (1 µM) and was found to … sims 4 not launching 2022 rc church leighton buzzard